Your immune system was designed to protect you—to mount a fierce defense, then stand down. But sometimes, long after the original threat has passed, that system fails to switch off. The fever breaks, the acute symptoms fade, yet your body remains in a state of internal alarm—reactive, inflamed, and unable to return to balance.
You might have fought COVID-19 months ago, yet still wake each day to a body that's never felt the same. Perhaps a flu others recovered from in a week triggered a cascade of sensitivities, allergic-type reactions, gut disturbance, and exhaustion that has quietly taken over your life. For some, symptoms emerge gradually, without a single clear trigger, but with the same relentless impact.
We recognise what others refuse to see: post-exertional malaise isn't laziness but a measurable energy crisis at the cellular level. Your inability to tolerate simple activities—a shower, a conversation, a walk to the mailbox—represents genuine metabolic dysfunction, not deconditioning. When you say you feel like you have the flu every day, or react unpredictably to food, environments, or stress, you’re describing real inflammatory and mast-cell-mediated processes.
These aren’t psychological symptoms—they’re the signature of a body whose immune system, energy production, and regulatory mechanisms have been profoundly disrupted.
This pathway recognises that immune-mediated illness exists at the intersection of immunology, neurology, autonomic function, and cellular metabolism. Normal blood tests do not exclude immune dysregulation, just as the absence of acute infection does not mean recovery has occurred. When clinicians focus only on what has resolved, they miss the physiological systems that remain under strain.
We understand that your illness is real—even when it is difficult to measure—and that immune dysregulation requires comprehensive, systems-based care rather than dismissal or simplification.
Captures viral history and onset patterns, post-exertional malaise documentation, multi-system symptom inventory, and functional impact assessment to map the full constellation of post-viral symptoms that distinguish cellular exhaustion from deconditioning.
Your specialist care coordinator conducts thorough assessment including comprehensive story collection with detailed viral timeline and functional capacity mapping, clinical measurements with active stand test and post-exertional response evaluation, autonomic symptom documentation, sleep and cognitive assessment, and integration planning for targeted medical investigations.
Systematic evaluation includes hormonal and metabolic assessment with comprehensive endocrine evaluation and advanced nutrient analysis, immune system investigation with inflammatory marker patterns and autoimmune screening, and testing for mast cell activation syndrome and connective tissue disorders when indicated.
If indicated, ambulatory assessment includes 24-48 hour Holter monitoring with heart rate variability analysis and activity correlation mapping, ambulatory blood pressure assessment with orthostatic response documentation and circadian pattern analysis, and advanced autonomic testing with COMPASS-31 correlation and cognitive-cardiovascular correlation.
Whether confirming ME/CFS, documenting Long COVID, or identifying chronic viral reactivation, you receive formal diagnostic documentation meeting IOM/WHO criteria, pathophysiology explanation, functional impact assessment, provider coordination letters, condition-specific education, pacing and energy management protocols, and treatment pathway recommendations.
Immune pathway conditions require more than symptom suppression alone—they demand targeted medical intervention that addresses immune dysregulation, chronic inflammation, and impaired immune resolution. Our medical practitioners use evidence-based pharmacological strategies alongside integrative medicine approaches to modulate immune activity, stabilise inflammatory responses, and support cellular metabolism. This includes immune-relevant nutrient repletion, mitochondrial support where indicated, and careful medication selection to address the biological drivers perpetuating immune activation.
Persistent immune activation frequently involves inappropriate mast cell signalling and histamine release, contributing to multi-system symptoms that mimic allergic reactions without true allergy. Our clinicians provide structured assessment and management of mast cell activation and histamine intolerance, including trigger identification, targeted antihistamine and stabilisation protocols, and lifestyle strategies to reduce immune reactivity. This approach helps calm the immune system’s over-alert state and reduce symptom volatility.
Immune dysregulation is closely linked to gut function, with microbiome imbalance and dysmotility contributing to ongoing inflammation and immune activation. Our dietitians, nutritionists and medical practitioners address gut–immune dysfunction through personalised nutrition strategies, microbiome support, and targeted interventions for food sensitivities, SIBO, and gastrointestinal dysmotility where indicated. The focus is on restoring gut signalling that supports immune regulation rather than perpetuating inflammatory cycles.
Immune-mediated illness commonly disrupts autonomic and cardiovascular stability, leading to orthostatic intolerance, POTS and dysautonomic symptoms that significantly limit function. Our team provides comprehensive autonomic support including pharmacological management, compression and volume strategies, and lifestyle modifications tailored to individual physiology. Interventions are designed to stabilise cardiovascular responses and reduce the fatigue and symptom flares associated with autonomic dysfunction.
Chronic immune activation often interferes with nervous system regulation, impairing parasympathetic function and stress recovery pathways. We offer evidence-based nervous system interventions, including transcutaneous Vagus Nerve Stimulation and the Safe and Sound Protocol, to support autonomic balance and improve immune–nervous system communication. These therapies aim to reduce hypervigilance, modulate inflammatory signalling, and support more stable physiological regulation.
When immune dysregulation limits physical and cognitive capacity, occupational therapy plays a critical role in preserving function without triggering symptom exacerbation. Our occupational therapists specialise in pacing, energy conservation, and adaptive strategies that respect post-exertional symptom responses. Support focuses on practical solutions for daily activities, cognitive load management, and sensory sensitivities, helping patients maintain independence while protecting limited energy reserves.
Movement within immune-mediated illness is not about fitness progression—it is about maintaining physiological stability and preventing deconditioning without provoking post-exertional crashes. Our exercise physiologists and physiotherapists develop carefully individualised movement programs guided by symptom patterns and heart rate monitoring, with an emphasis on consistency rather than intensity. Programs adapt to fluctuating tolerance and prioritise nervous system and immune stability over performance gains.
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