Dysautonomia Pathway

POTS (Postural Orthostatic Tachycardia Syndrome)
MCAS (Mast Cell Activation Syndrome)
Trauma-Induced Dysautonomia
Inappropriate Sinus Tachycardia
Orthostatic Hypotension

Understanding your story...

Your autonomic nervous system operates beneath conscious thought—calibrating every heartbeat, adjusting every blood vessel, coordinating the thousand invisible recalibrations that keep you alive. When this exquisite machinery falters, your body becomes a stranger to itself. Standing transforms into a physiological crisis. A shower becomes an endurance event.

You might live with a heart rate that soars from 70 to 150 just by standing. Perhaps you've mastered the subtle art of pre-syncope—that grey-vision, cold-sweat dance at the edge of consciousness that others can't see but you navigate daily. Maybe your nervous system still responds to safety as threat—the lasting physiological echo of trauma medicine has only recently learned to measure.

We understand what others dismiss: orthostatic intolerance isn't deconditioning when you were an athlete six months ago. Your need to lie flat mid-conversation isn't drama—it's your brain protecting itself from hypoperfusion. The crushing fatigue after standing in a queue isn't laziness but your body fighting gravity with broken weapons.

These aren't anxiety symptoms—they're the measurable, predictable consequences of autonomic dysfunction that we know how to identify, validate, and treat.

POTS (Postural Orthostatic Tachycardia Syndrome)

Key Features
Heart rate increase ≥30bpm (adults) or ≥40bpm (12-19) on standing, without hypotension
Diagnostic Approach
Active stand test, autonomic function assessment, pathology, subtype identification

MCAS (Mast Cell Activation Syndrome)

Key Features
Multi-system allergic-type reactions without true allergy
Diagnostic Approach
Tryptase/histamine metabolites during flares, systematic trigger identification

Trauma-Induced Dysautonomia

Key Features
Autonomic dysfunction following psychological trauma, hypervigilant stress responses, somatic manifestations
Diagnostic Approach
Trauma-informed autonomic assessment, polyvagal mapping, ACE correlation studies

Inappropriate Sinus Tachycardia

Key Features
Persistent elevation of resting heart rate >100bpm
Diagnostic Approach
24-hour Holter monitoring, exclusion of secondary causes, autonomic profiling

Orthostatic Hypotension

Key Features
Sustained BP drop ≥20/10mmHg within 3 minutes of standing
Diagnostic Approach
Comprehensive orthostatic assessment, distinguishing neurogenic from non-neurogenic causes

It's all connected

/ your care must be too

This pathway recognises that dysautonomia rarely travels alone—and that its origins are as varied as its presentations.

Your POTS might coexist with the connective tissue disorder that predisposed you to it. Your trauma history might have created the autonomic instability that makes every day a physiological marathon. Your mast cell activation amplifies your orthostatic symptoms.

We don't force you to choose which specialist to see or which origin story matters most—we understand that your autonomic dysfunction is the common thread weaving through multiple diagnoses, demanding integrated treatment that addresses both cause and consequence.

Find the answers you're needing with a dedicated diagnostic pathway

Our carefully crafted diagnostic pathway transforms years of medical uncertainty into clear answers through systematic assessment that honours both your lived experience and the latest clinical science.
1
Digital Pre-Screening

Comprehensive questionnaires capture detailed symptom inventory, COMPASS-31 autonomic assessment, trauma/stress history, and trigger identification to map your autonomic reality rather than dismiss it as anxiety.

2
Comprehensive Autonomic Assessment

A thorough 60-90 minute assessment includes active stand testing, symptom correlation mapping, functional capacity evaluation, onset pattern analysis, and comprehensive story collection that connects your daily experiences to measurable physiological patterns.

3
Medical Investigation

Comprehensive evaluation identifies specific dysautonomia subtypes through POTS subtype investigation, underlying cause analysis, and targeted laboratory assessment including hormonal evaluation, metabolic profiling, MCAS investigation, and connective tissue screening.

4
Advanced Monitoring

If indicated, 24-48 hour Holter monitoring, ambulatory blood pressure assessment, and at-home HRV tracking provide precise documentation of heart rate variability, arrhythmia detection, and circadian rhythm patterns.

5
Diagnosis & Documentation

Formal diagnostic documentation, subtype-specific care plans, educational resources, and provider coordination letters ensure your entire healthcare team understands your specific constellation of autonomic dysfunction.

Find relief and recover function with evidence-based interventions

POTS Diagnosis & Treatment

POTS sits in the dysautonomia pathway as both an arrival point and an ongoing clinical question. People often arrive after weeks or years of symptoms that change with standing, heat, meals or exertion. The work of this part of the pathway is to assess what the autonomic system is actually doing, name the contributing patterns, and connect that reading to the rest of the patient's care.

Cardiac Investigations

Cardiac investigations sit in the dysautonomia and connective tissue pathways because diagnosing and phenotyping POTS, orthostatic intolerance and other autonomic-cardiovascular pictures depends on capturing what the heart and blood pressure actually do across daily activity — not just at one moment in a consultation. The work is structured, targeted use of Holter monitors, ambulatory blood pressure monitors, and standardised orthostatic testing such as the NASA Lean Test.

Medication Management

Medication management sits in the dysautonomia pathway because pharmacological options for autonomic dysregulation are individual — what stabilises one person's heart rate may destabilise another's blood pressure, what raises one person's standing tolerance may worsen another's recovery. The work of this part of the pathway is to read the autonomic picture, choose carefully, monitor explicitly, and adjust against what the body actually does.

Integrative Medicine

Integrative medicine sits in the dysautonomia pathway because autonomic dysfunction rarely arises in isolation. The work of this part of the team is to read what may be driving or sustaining the dysregulation — post-viral physiology, mast-cell activity, nutritional state, hormonal shifts, sleep — and to decide what medical management is useful alongside the rest of the plan.

Hormone Replacement Therapy

Hormone replacement therapy sits in the dysautonomia and immune pathways because hormonal change — perimenopause, menopause, thyroid dysfunction, post-pill — can shape and worsen autonomic dysregulation, mast-cell activity and fatigue patterns. The work of this part of the team is to read the hormonal picture against the autonomic and immune picture and decide whether hormonal support belongs in the plan.

Intravenous Fluids (Saline)

IV fluids sit inside the dysautonomia pathway as an adjunct, not a primary treatment. For some people they reduce orthostatic symptoms during a flare, during recovery from a viral episode, or during a hotter-than-usual week. How a person responds to fluid therapy also tells the clinical team something about which sub-pattern of POTS is most active.

Transcutaneous Vagus Nerve Stimulation

tVNS sits inside the dysautonomia pathway as one tool among several. It uses gentle electrical stimulation of the vagus nerve at the ear to support the parasympathetic side of autonomic regulation. The work is at the level of the nervous system's underlying balance, not at the level of individual symptoms.

Exercise Physiology

Exercise physiology sits in the dysautonomia pathway because exercise intolerance in autonomic dysfunction has two different shapes. Where cardiovascular deconditioning is the dominant story, graded recumbent reconditioning can rebuild capacity over months. Where post-exertional malaise is part of the picture — ME/CFS, long-COVID and similar post-viral states — the same approach causes harm, and the work is pacing inside an energy envelope. The first job of this part of the pathway is to tell those two pictures apart, and to prescribe accordingly.

Integrative Physiotherapy

Integrative physiotherapy sits in the dysautonomia pathway because movement, posture, breath and the autonomic system are continuously shaping each other. The work of this part of the team is to read those interactions, address the parts that physiotherapy can help, and coordinate with the rest of the autonomic plan.

Trauma Therapies

Trauma therapies sit in the dysautonomia pathway because trauma — medical, relational, developmental — and autonomic dysregulation are physiologically connected. Chronic illness itself is often traumatic; medical experiences across years of poorly understood symptoms can leave a nervous system held in defence. The work is therapy approaches that fit this nervous system, not against it.

Eating Disorder Care

Eating disorder care sits in the dysautonomia pathway because the overlap between POTS, autonomic dysfunction and eating disorders is clinically significant — and standard eating-disorder treatment, designed for bodies without the autonomic and circulatory picture, often does not fit. The work is structured eating-disorder care delivered by a credentialed clinician who understands the dysautonomic picture and works with the rest of the team to keep the autonomic side stable.

Clinical Dietetics

Clinical dietetics sits in the dysautonomia pathway because food, fluid and digestion are part of how the autonomic system is regulated. People in this pathway often find that meals change how they stand, how they think, and how they recover. The work of this part of the pathway is to read those patterns and build a nutrition structure that does not work against the rest of the plan.

Occupational Therapy

Occupational therapy sits in the dysautonomia pathway because the daily life of someone with autonomic dysfunction — POTS, ME/CFS, long-COVID, post-exertional malaise — is shaped by limits that ordinary occupational therapy does not assume. The work is to read how the day is being spent, where the cost is appearing, and to build an energy and activity structure that fits the body in front of the clinician rather than a generic one.

Care Coordination

Care coordination sits in the dysautonomia pathway because the work across a dysautonomic presentation has a lot of moving parts. Autonomic medicine, cardiac investigations, medication titration cycles, exercise physiology paced against autonomic tolerance, dietetic structure, sometimes mental-health work. Each part needs the others to know what it is doing. The coordinator holds that picture across the plan, beginning inside the biio.markers assessment.

Safe & Sound Protocol (Long-COVID)

The Safe & Sound Protocol sits inside the dysautonomia and post-viral pathways as a tool aimed at the regulation level. It uses specifically filtered music to engage vagal pathways through the auditory system, supporting the parasympathetic side of the autonomic picture. It works alongside other parts of the plan rather than instead of them.

Magnesium Infusions for Headaches & Migraine

Intravenous magnesium infusions offer powerful dual action against migraines, delivering rapid relief during acute attacks while helping prevent future episodes through their restorative effect on neurological pathways. This natural mineral approach works by immediately calming overactive pain receptors and relaxing constricted blood vessels, with clinical studies showing most patients experience significant relief within an hour and up to 43% reduction in migraine frequency with regular treatment.

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